Dab tsi yog Kev Noj Qab Haus Huv-Txhawb Cov Khoom ntawm Proanthocyanidins rau plab hnyuv plab?

Dab tsi yog qhov Amazing PAC Ntxiv? Nws nyob qhov twg?

95% Proanthocyanidin hmoovfeem ntau yog cais los ntawm cov txiv hmab txiv ntoo los yog ntoo thuv bark. Proanthocyanidins yog cov tshuaj sib xyaw ua ke. Lawv muab cov txiv hmab txiv ntoo los yog paj ntawm ntau cov nroj tsuag muaj xim liab, xiav, lossis ntshav liab. Ua ntej, kawm lawv qhov tseem ceeb li phytochromes. Cov tshuaj no tuaj yeem pab tiv thaiv qog noj ntshav. Proanthocyanidins belongs rau ib pawg ntawm cov tshuaj hu ua polyphenols. Cov tshuaj no muaj nyob rau hauv subclass hu ua flavonoids.

Cov khoom noj uas muaj ntau ntawm proanthocyanidins suav nrog txiv hmab txiv ntoo liab, txiv hmab txiv ntoo dub, txiv hmab txiv ntoo, txiv hmab txiv ntoo liab, bilberries, cranberries, strawberries, blueberries, liab cabbage, ntoo thuv bark, thiab lingonberry nplooj, birch, thiab ginkgo.

Intestinal Barrier yog dab tsi?

Lub luag haujlwm tseem ceeb ntawm txoj hnyuv yog zom cov khoom noj khoom haus thiab nqus cov as-ham thiab dej los ntawm lumen mus rau hauv lub cev. Lub plab kuj yog lub cev tiv thaiv kev sib cuag nrog ib puag ncig. Raws li qhov tshwm sim, lub plab hnyuv epithelium tau raug txuas mus rau cov kab mob pathogenic microorganisms, co toxins, thiab cov khoom tsis zoo ntawm cov khoom noj. Thaum muaj kev cuam tshuam ntawm kev ua haujlwm thiab kev tiv thaiv mucosal homeostasis raug cuam tshuam, kev nkag mus ntawm cov hnyuv tuaj yeem ua rau muaj kev tiv thaiv kab mob ntau dhau. Thaum kawg, kev raug mob rau cov teeb meem ib puag ncig stimuli tuaj yeem ua rau kev loj hlob ntawm ob qho tib si hauv zos thiab cov kab mob hauv lub cev.

Lub luag haujlwm ntawm Proanthocyanidins (PACs) yog dab tsi hauv Kev Txhawb Txoj Kev Noj Qab Haus Huv?

Cov ntaub ntawv pov thawj los ntawm kev sim tsiaj txhu thiab cov kab lis kev cai ntawm tes qhia tau hais tias kev kis kab mob hauv plab mus rau proanthocyanidin-nplua nuj cov khoom cog xws li cov noob txiv hmab txiv ntoo tuaj yeem pab tswj kev ua haujlwm tsis zoo thiab txhim kho cov kab mob uas tshwm sim hauv kev noj zaub mov kom rog thiab kab mob plab hnyuv.

Cov khoom txhawb nqa kev noj qab haus huv ntawm PACs hauv plab yog qhov tshwm sim tsis yog tsuas yog muaj cov tshuaj tiv thaiv antioxidant ntawm phenolic compounds, tab sis kuj muaj peev xwm ntawm cov phytochemicals no cuam tshuam nrog ntau yam biomolecules, suav nrog cov proteins, biofilm lipids, thiab endotoxins. Kev ua haujlwm lom neeg ntawm PACs vam khom rau cov qauv, thiab cov tshuaj ntsuab muaj txiaj ntsig zoo los ntawm ntau cov qauv molecular ua si ntau yam tsis cuam tshuam txog lub cev. Nyob rau hauv txoj kev no, PAC tshuaj tuaj yeem tswj hwm kev ua haujlwm kinase, ntau txoj hauv kev hloov pauv cov teeb liab cuam tshuam nrog cov lus teb inflammatory, thiab TJ hloov kho. Flavan-3-ol monomers thiab luv PAC oligomers raug coj los ntawm enterocytes thiab lub cev tiv thaiv kab mob thiab ua ncaj qha rau ntawm kinases thiab cov ntsiab lus hloov pauv. Kev ua haujlwm lom neeg ntawm cov oligomeric thiab polymeric PACs loj dua tsis tas yuav muaj kev nqus ncaj qha rau hauv plab thiab muaj peev xwm los khi rau cov protein receptors ntawm cov kab mob enterocytes thiab lub cev tiv thaiv kab mob, nrog rau cov kab mob luminal endotoxins, yog li inhibiting pro-inflammatory signaling thiab txhim kho kev ruaj ntseg barrier. Nrog kev nqus tsis zoo ntawm PAC loj molecules nyob rau hauv txoj hnyuv me, phenyl- -valerolactones thiab phenolic acids metabolized los ntawm colonic microbiota tau xav tias ua lub luag haujlwm tseem ceeb hauv cov teebmeem kev noj qab haus huv.

Dab tsi yog PAC Cov Teeb Meem thiab Cov Txheej Txheem ntawm Kev Ua Raws Li Txoj Cai Ua Kab Mob?

Nyob rau hauv OxS tej yam kev mob, pro-inflammatory cytokines yog tshwm sim nyob rau hauv cov hnyuv epithelial hlwb. Ntau qhov kev sim tau lees paub qhov kev soj ntsuam no los ntawm kev ua kom pom Fe / Asc-mediated induction ntawm qog necrosis factor- (TNF). Raws li cov ntaub ntawv no, cov prooxidant Fe/Asc tau nce cov protein qhia ntawm cyclooxygenase-2 (COX2), ib qho enzyme nrog ntau lub luag haujlwm hauv kev txhawb nqa thiab kev kho mob. Txawm li cas los xij, PAC cov thawj coj tawm tsam Fe / Asc-induced TNF thiab COX2 protein ntau. Txawm hais tias Fe / Asc-kev sib tw Caco-2/15 hlwb tuaj yeem pom cov NF-κB siab qhia los ntawm kev ua kom muaj NF-κB / IκB piv thiab phosphorylation ntawm nws inhibitor κappa B (IκB), PACs muaj peev xwm cuam tshuam nrog NF-κB txoj hauv kev, raws li kev cuam tshuam los ntawm lawv qhov inhibition ntawm NF-κB thiab txo qis hauv IκB phosphorylation / IκB piv, uas tau txhim kho los ntawm Fe / Asc. Yog li, PAC ua raws li lub zog inhibitor ntawm o.

Yog tias koj muaj kev mob plab hnyuv, sim peb95% Proanthocyanidin hmoovthiab koj yuav xav tsis thoob ntawm qhov tshwm sim. Nrhiav rau pem hauv ntej rau koj kev sib cuag ntawmapril@inhealthnature.com.